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Genetic Association Between Myopic Refractive Error and Primary Open-Angle Glaucoma


Title: Genetic Association Between Myopic Refractive Error and Primary Open-Angle Glaucoma


What are the key takeaway points from this article?

Refractive error is the most common cause of impaired vision. It is known that myopic refractive error is associated with an increased risk of primary open-angle glaucoma (POAG); however, a causal role has not yet been established. This observational study evaluated the role of genetic overlap to investigate the association between myopic refractive error with POAG. Genetic overlap was quantified in 154 018 individuals from the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort using genetic correlation analysis and genome-wide association studies. It was found that POAG was genetically correlated with mean spherical equivalent refractive error, myopia, and high myopia. Thus, a shared genetic association was found between myopic refractive error and POAG. This has relevance in population POAG risk stratification based on refractive error status to enable earlier diagnoses and preventative strategies.


Publication Date: July 28th, 2022


Reference: Choquet H, Khawaja AP, Jiang C, et al. Association Between Myopic Refractive Error and Primary Open-Angle Glaucoma: A 2-Sample Mendelian Randomization Study. JAMA Ophthalmol. 2022;140(9):864–871. doi:10.1001/jamaophthalmol.2022.2762


Summary by: Sarah Yeo

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